Olufemi R Ayeni,1 Marcin Kowalczuk,1 Jordan Farag,1 Forough Farrokhyar,1,2 Raymond Chu,1 Asheesh Bedi,3 Kevin Willits,4 Mohit Bhandari1,2 1Division of Orthopaedic Surgery, Department of Surgery, 2Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada; 3Department of Orthopaedic Surgery, University of Michig
We investigated a possible drug efficacy enhancement obtained by combining inactive doses of galantamine and memantine in the scopolamine-induced amnesia model in mice.We evaluated the effects of the two drugs, either alone or in combination, using the spontaneous alternation Exercise Peddlers and object recognition tasks.In both tests, combination
The interaction between chemokine receptor type 4 (CXCR4) and its ligand, stromal cell-derived factor (SDF)-1, plays an important role in stem cell mobilization and migration in ischemic tissues.MicroRNAs (miRs) are key regulators of stem cell function and are involved in regulation of stem cell survival and differentiation to adopt different cell
Objective: To study the Shirt effect of inter medin(IMD) on smooth muscle of rat seminal vesicles including the specific receptors and the signal pathways involved.Methods: The contraction of the seminal vesicle in response to norepinephrine (NE) and ADM2/IMD was studied by the organ bath method.The effects of antagonists for calcitonin gene relate
In just a few months, the current coronavirus pandemic has exposed the need for a more global approach to human health.Indeed, the quick spread of infectious diseases and their unpredictable consequences, in terms of human lives and economic losses, will require a change in our strategy, both at the clinical and the research level.Ultimately, we sh